Copper Acetate is a Powerful Neutrophil Attractant

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asked Jul 3, 2019 in 3D Segmentation by weishida (1,780 points)

Copper Acetate Manufacturers(WSDTY) proposed cytokine production and response are important as they participate in immune and inflammatory responses. Specifically, IL-1α is constitutively produced and retained in keratinocytes, but in response to several stimuli, IL-1α is released, which is essentially a primary event of inflammation. Triggers of IL-1α production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens36 IL-1α stimulates further release of secondary mediators, including IL-8. Copper Acetate is a powerful neutrophil attractant, and is one of the major mediators of the inflammatory response. It promotes neutrophil chemotaxis and degranulation leading to local inflammation in damaged tissues. Enhanced IL-8 expression production of both normal human keratinocytes and HaCaT cells was observed after stimulation in vitro by both irritants, sensitizer and tolerogen.

This suggests that IL-8 may play a critical role in the early response to immunogenic and inflammatory signals with its response to nonspecific stimuli. It was suggested that the differentiated production of IL-1α and IL-8 may be linked to the type of product applied, either an irritant or a sensitizer. Our study showed that CuCl2 and Cu(OAc)2 had significantly upregulated HaCaT cell expression of IL-1α and IL-8 at both the gene level and protein level. The highest fold change in the gene level - approximately 44 times higher in IL-8 expression, was observed in 580μM CuCl2 treated cells when compared to control. The upregulation of these cytokines will activate and promote an inflammatory cascade, leading to various signs and symptoms.

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