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While mutations in the protein, known as otoferlin, are linked to severe congenital hearing loss Cheap Air Jordan 12 , a common type of deafness in which patients can hear almost nothing, the research suggests that otoferlin, which is in the cochlea of the inner ear, acts as a calcium-sensitive linker protein.
Published recently in the Proceedings of the National Academy of Sciences, or PNAS Cheap Jordan 12 Retro Clearance , the study also shows that a mutation in otoferlin weakens the binding between the protein and a calcium synapse in the ear, and deficiencies in that interaction might be at the root of hearing loss related to otoferlin, which is difficult to study due to the size of its molecule.
"Otoferlin seems only to have one purpose and that is to encode sound in the sensory hair cells in the inner ear Cheap Jordan 12 Retro From China ," corresponding author Colin Johnson, associate professor of biochemistry and biophysics, explained in a news release from OSU Monday. "And small mutations in otoferlin render people profoundly deaf."
The work by Johnson and his collaborators provides a molecular-level explanation for the observation that otoferlin and synaptotagmin don't have the same functional role. Air Max 90 Sale Wholesale Jerseys China Cheap Wholesale NHL Jerseys China Wholesale NFL Jerseys Cheap Wholesale College Jerseys Wholesale College Basketball Jerseys Wholesale Basketball Jerseys Wholesale Basketball Jerseys Wholesale MLB Baseball Jerseys Cheap NBA Basketball Jerseys