Tiamulin
Fumarate Premix
[Main
Component]
Tiamulin Fumarate
[Description]
This product is white to off-white
crystal granular.
[Pharmacological
Action]
Pharmacology
Tiamulin Fumarate belongs to
pleuromutilin antibiotics, and has bactericidal effect against sensitive
bacteria in high concentration. By means of combination with ribosome 50S
subunit, Tiamulin Fumarate shall suppress bacteria protein synthesis.
Tiamulin
Fumarate has satisfactory anti-microbial activity against mycoplasma and swine treponema
hyodysenteriae, and as well as preferable antibacterial activity against most
gram-positive bacteria, including staphylococcus, streptococcus(except for
group D streptococcus). It also play a role against actinobacillus
pleuropneumoniae, and has relatively low antibacterial activity against most
gram-negative bacteria.
This
product shall be compatible with aureomycin at the ratio of 1:4, and it is
treatable to swine bacterial enteritis, bacterial pneumonia, treponema-caused
swine dysentery. It also has remarkable effect on mycoplasma pneumonia, and pneumoniacaused
by combination infection of bordetella bronchisepticaand pasteurella multocida.
Pharmacokinetics
Significant
absorption effect for swine oral administration. Bioacailability is about 85%
after single dose administration, and peak serum
concentration occur after 2~4 hours. And drug is wide spreading in animal
body, and the highest density comes up at lung tissue. Tiamulin Fumarate is
broadly metabolized in animal body, then turns into more than 20 kinds of
metabolites, some of which has antibacterial activity. And Tiamulin Fumarate
metabolites is mainly excreted as feces via bile, and about 30% excreted as
urine.
[Pharmacological interaction]
(1) Feeding
together with polyether antibiotics, such as Monensin, Salinomycin, and
Narasin, etc, will give rise to slow growth, ataxia, paralytic syndromes, even
death.
(2) If
use together with other ribosome 50S subunit-combining antibiotics(such as
macrolides antibiotics, lincomycin), drug function will be reduced due to their
competition on same action site.
[Effect and function]
Pleuromutilin
antibiotics. It is mainly used as precaution and treatment for swine mycoplasma
pneumonia, actinobacillus pleuropneumoniae, and swine dysentery caused by
treponema.
[Usage and dosage]
Premix
10%: Calculated based on this product.
Mixed in
feedstuff: every 1000kg feedstuff, 400~1000g for swine, continuous use for 5~10
days.
Premix
80%: Calculated based on this product.
Mixed in
feedstuff: every 1000kg feedstuff, 50~125g for swine, continuous use for 5~10
days.
[Side effect]
Normal
dosage for swine, sometimes skin erythema occurs. If over-dosed, it might cause
swine short salivation, vomit and central nervous depressant.
[Notice]
(1)
Forbidden to use together with polyether antibiotics, such as Monensin,
Salinomycin, and Narasin, etc.
(2)
Avoid exposure to eye and skin.
(3) If
environment temperature is above 40℃, feedstuff mixed with
this product shall be stored within 7 days.
[Withdrawal period]
7 days
for swine.
[Specification]
10%,
80%
[Package]
25kg/bag
(Premix 10%), 20kg/drum (Premix 80%)
[Storage]
Keep
airtight and shading in a dry place at room temperature.
[Validity]
2
years.
https://www.shenglipharm.com/tiamulin-fumarate-premix/