Immunoglobulin (Ig) G is the major antibody of the secondary immune response and has the longest half-life of the five immunoglobulin classes (IgA, IgD, IgE, IgG, and IgM) due to recycling by the neonatal Fc receptors (FcRn). Because lacking protection by FcRn, some shortcomings of the short half-life of non-IgG antibodies largely limit their potential for application, such as rapid blood clearance, rapid shedding rates, and poor retention times on targets (e.g., tumors). At present, Creative Biolabs is glad to introduce the antibody half-life extension service for non-IgG antibodies to improve stability and performance.