High mobility group box 1 (HMGB1) is a nuclear protein involved in the pathogenesis of a variety of chronic inflammatory and autoimmune diseases. In addition, HMGB1 is also a bone-active cytokine that is released from necrotic osteocytes and participates in bone remodeling, and plays a role in bone formation within cartilage. HMGB1 is associated with rheumatoid arthritis (RA) and osteoarthritis (OA), so it can be served as an important biomarker for these two diseases. Creative BioMart Biomarker offers high quality detection service for HMGB1, ensuring high detection accuracy, sensitivity and efficiency for each sample.