Zebrafish (Danio rerio) is a growing vertebrate model for research and has been used to answer pertinent scientific questions in a variety of biomedical research fields including neuroscience, developmental biology, toxicology, oncology and many others. The use of zebrafish in biomedical research has increased and diversified significantly in the past 30 years. The health status in zebrafish, like other animal models, can be highly impactful on the research outcomes.