Polycystic kidney disease (PKD) is a common autosomal inherited disease, which is single-gene inherited. It is genetically divided into dominant and recessive categories. Both types cause bilateral kidney disease. Among them, autosomal dominant polycystic kidney disease (ADP KD) is the most common, mainly characterized by the continuous formation and expansion of fluid-filled vesicles derived from renal tubular epithelial cells, and typical cases will develop into end-stage kidneys in middle age stages of disease. ADPKD is more common than adulthood, with high incidence and poor prognosis. At present, there is no effective treatment in clinic. Therefore, since the first pathogenic gene of ADPKD was discovered, researchers have done a lot of research and exploration on its pathogenesis and treatment methods.