Congenital insensitivity to pain is a genetic disorder of sensory autonomic nervous system. In patients with this type of disease, the transmission of pain is blocked, that is, pain sensation is dull or lost, and may be accompanied by anhidrosis, but the intelligence and sensory abilities such as cold and heat, vibration, and movement perception develop normally. Complete loss of pain means loss of alertness to harmful stimuli. A life system with complex regulatory functions will not easily lead to self-destructive "painless". It is estimated that including those who have not been diagnosed, there may be fewer than 40 painless and sweat-free patients in the world. Pain-free and sweat-free disease is still an unsolved mystery in medical circles all over the world.