RNA is subject to epigenetic modifications, and the post-translational modifications to RNA that can impact numerous biological processes have gained acceptance as a dynamic epigenetic mark. N6-methyladenosine (m6A) is the most common and abundant modification in messenger RNA and has been linked to diverse effects on mRNA fate. The in-depth study of its distribution and functions has revealed that m6A is typically near the stop codon, but also in the coding sequence, 3′UTR, and 5′UTR of mRNAs.