Joe Rogan Supplements critical for the function of the sirtuin genes, genes which help us live longer. He describes resveratrol as the “accelerator pedal” for the sirtuin genes (increasing their activation), and NMN as the fuel. The reason that resveratrol won’t work effectively without NMN (the “fuel”), is that sirtuin activation requires youthful NAD levels, but NAD levels decline with age, and by 50 years old, we have about half the level of NAD we had in our 20s (NAD being a molecule that is essential to energy production in our cells). So in effect, you take resveratrol to increase activation of the sirtuin genes, and NMN to ensure the sirtuins have enough energy to work properly. It’s worth noting that restoring NAD levels has other helpful benefits too.
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