Copper Acetate Manufacturers(WSDTY) proposed cytokine production and response are important as they participate in immune and inflammatory responses. Specifically, IL-1α is constitutively produced and retained in keratinocytes, but in response to several stimuli, IL-1α is released, which is essentially a primary event of inflammation. Triggers of IL-1α production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens36 IL-1α stimulates further release of secondary mediators, including IL-8. Copper Acetate is a powerful neutrophil attractant, and is one of the major mediators of the inflammatory response. It promotes neutrophil chemotaxis and degranulation leading to local inflammation in damaged tissues. Enhanced IL-8 expression production of both normal human keratinocytes and HaCaT cells was observed after stimulation in vitro by both irritants, sensitizer and tolerogen.
This suggests that IL-8 may play a critical role in the early response to immunogenic and inflammatory signals with its response to nonspecific stimuli. It was suggested that the differentiated production of IL-1α and IL-8 may be linked to the type of product applied, either an irritant or a sensitizer. Our study showed that CuCl2 and Cu(OAc)2 had significantly upregulated HaCaT cell expression of IL-1α and IL-8 at both the gene level and protein level. The highest fold change in the gene level - approximately 44 times higher in IL-8 expression, was observed in 580μM CuCl2 treated cells when compared to control. The upregulation of these cytokines will activate and promote an inflammatory cascade, leading to various signs and symptoms.
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