The main active ingredients in Sildalist 120 and Vidalista 20 are sildenafil citrate and tadalafil, respectively. These are both phosphodiesterase type 5 (PDE5) inhibitors used for the treatment of erectile dysfunction (ED). While both medications belong to the same class of drugs and are effective in treating ED, they differ primarily in their pharmacokinetic profiles, onset of action, and duration of effect.
Sildenafil citrate, the active ingredient in Sildalist 120, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. This inhibition leads to increased levels of cGMP, resulting in smooth muscle relaxation, vasodilation, and increased blood flow to the penis, ultimately facilitating an erection. Sildalist 120 typically starts working within 30 to 60 minutes after ingestion and has a duration of action of up to 36 hours.
On the other hand, tadalafil, the active ingredient in Vidalista 20, also works by inhibiting PDE5 but has a longer duration of action compared to sildenafil citrate. Tadalafil has a slower onset of action, typically taking effect within 30 minutes to 2 hours after ingestion, but its effects can last for up to 36 hours. This prolonged duration of action has earned tadalafil the nickname "the weekend pill," as it allows for greater spontaneity and flexibility in sexual activity compared to other ED medications.