| crystallization chaperone complex | Membrane proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are important drug targets. However, structure-based drug discovery (SBDD) is hampered by the lack of the corresponding 3D protein models, mostly due to the difficulty of crystallizing membrane proteins in their native state. One strategy to address this problem is to prepare the target membrane proteins in complex with covalent or non-covalent bound soluble protein chaperones that are highly intrinsic to crystallize. |