Cryo-electron tomography (cryo-ET) is an approach for resolving polymorphic structures such as cells and organelles in a near-natural state and can provide a three-dimensional (3D) snapshot of viral particles in the host cell environment. The cryo-electron microscopy (cryo-EM) single-particle analysis (SPA) technology is usually utilized to study single particles, mainly macromolecular complexes or viral particles with regular shapes that have been isolated and purified by biochemical methods. Creative Biostructure provides cryo-ET services that allow you to obtain structural information about viral particles, as well as their spatial arrangement in the cell/tissue environment and view their interaction with other molecules in vivo.