Antibody-dependent enhancement (ADE) mainly refers to an effect in the body, which is caused by pathogen infection. In 1964, Hawkes and his team from the Australian National University first put forward the hypothesis of "antibody-dependent enhancement of infection" in arboviruses and named it ADE. ADE showed that virus replication was promoted rather than inhibited in low concentrations of immune serum. At present, a variety of viruses have been found to have ADE effects, such as Ebola virus, West Nile virus, dengue virus, hepatitis C virus, and rabies virus.