Surgery is the only way to cure liver cancer, and only early liver cancer has such a chance. However, because most patients with liver cancer have liver cirrhosis, or most of the patients have reached the middle and advanced stages at the time of diagnosis, about only 20%-30% of patients will eventually get the chance of surgical resection. In addition to surgery, local treatment methods include hepatic artery embolization chemotherapy, percutaneous radiofrequency ablation therapy, radiotherapy, etc.; systemic treatment includes chemotherapy, targeted therapy, and immunotherapy. Among them, immune cell therapy seems powerful to fight against cancer cells to achieve anti-tumor effects. The immune cell therapy currently approved and used in clinical includes: dendritic cell vaccine therapy, αβ T cell therapy, γδ T cell therapy, NK cell therapy, etc.