Nano-biological conjugated technology brings hope for the treatment of gliomas and other neurodegenerative diseases. Glioma is the deadliest type of cancer, and the options for treatment are very limited. In December 2010, scientists in the United States and Germany developed a multifunctional Nano-biological conjugated technology, which provided the ability to transport antisense oligodeoxynucleotides (AONs) across the blood-brain barrier (BBB) and the blood-brain tumor barrier (BTB), and targeted their payloads at tumors for receptor-regulated cell uptake, intracellular escape and release into the cytoplasm.