Niiodophenol nitrile is a new type of insecticide for liver tablets. It is less effective than injection when taken internally. Subcutaneous injection has similar efficacy with intramuscular injection, but subcutaneous injection is mostly used clinically.The mechanism of deinsectization is to block the oxidative phosphorylation process, reduce the ATP concentration, and reduce the energy supply of the insect, resulting in the death of the insect.It had good effect on flukes in liver of cattle and sheep, adults of flukes in both front and rear plates, and also had good effect on flukes in liver of pig, blood pike nematode of sheep and ascaris of dog.An experimental study on the effects of niiodophenonitrile on mitochondrial function in rat hepatocytes demonstrated that it was a decoupling Chemicalbook conjugate for oxidative phosphorylation.The peak plasma concentration can be reached after injection of niiodophenolic eyeball into the sheepskin for 30min, and the drug is quickly absorbed.After the adult parasite ingested the host blood, the reaction of ATP production in the mitochondria of the parasite cells could be uncoupled, so as to reduce the concentration of ATP and eventually lead to the death of the parasite, to achieve the purpose of insecticidal.Because the drug is highly binding to plasma proteins in the blood (binding rate & GT;97%), which has a slow-release effect and has a long retention time in the host body. Therefore, the insect body can be kept in a drug environment for a long time to give full play to its inhibitory effect on the larvae.
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