2-Hydroxypropyl-β-cyclodextrin is the most widely used modified cyclodextrin.It has shown to change the physicochemical properties of lipophilic compounds when co-administered. It has the best balance of enhanced aqueous solubility, a wide range of drugs with which it forms stable complexes, and the most extensive collection of safety data in the technical literature with no adverse reactions reported.It is very soluble in water.
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