Many people believe that the strong pressure of weaning will lead to intestinal damage, and the convergence of Basic Copper Carbonate is just right. Is this a matter of course? If this is the case, the so-called basic copper carbonate coating should be better, and I know the actual effect is not as we expected (it may be due to experimental design factors).
What effect does basic copper carbonate have on intestinal flora?
Within 2 weeks after weaning, basic copper carbonate significantly inhibited Escherichia coli, but after 2 weeks, the result of intestinal flora was a decrease in lactic acid bacteria, an increase in Clostridium and a change in the proportion of Enterobacter. In addition, high copper diet will lead to the formation of multi-drug resistant Escherichia coli strains.
It is hard to say to what extent this change is affected by diet structure and to what extent the effect of basic copper carbonate is affected. Let's resume the "earthquake" that occurred in the intestinal tract after weaning. Under normal circumstances, the main energy source of the small intestine is amino acids, and the main component of the large intestine is short-chain volatile fatty acids. After weaning, the small intestine energy is insufficient and collapses due to reduced digestibility of feed protein and excessive pressure. More undigested proteins are poured into the large intestine, which provides a rich diet for Enterobacteriaceae and enables them to grow vigorously. At this time, it is no longer a "neutral pathogen" because it meets the conditions of its disease and is therefore ill. As a result,
The reason why Basic Copper Chloride has a good inhibitory effect on weaning diarrhea is that I think it plays the role of broad-spectrum antibiotics. More directly, it has the inhibitory effect on Enterobacter, that is, the effect of combining with anti-enzyme to treat Escherichia coli. Unfortunately, e coli developed multidrug resistance 2 weeks later. Further observation of the resistance genes of Enterobacteriaceae bacteria to tetracycline, sulfonamide and quinolone drugs showed that the antibiotic resistance began to increase after 1 week of copper application. Therefore, the EU has restricted the use of basic copper carbonate.
Prolonging the use of basic copper chloride to 3 to 4 weeks after weaning will reduce the production of short chain fatty acids at the intestinal end. This may be an adverse reaction to basic copper chloride because pigs use these metabolites as energy reserves. For colon, 80% of its energy comes from butyric acid produced by intestinal microorganism fermentation fibers. This also proves that basic copper chloride has a longer lasting inhibitory effect on bacteria that ferment carbohydrates.