Know about diabetes mellitus: You StrictionBP Review should seek information concerning your condition and what you must do to help yourself. You are also encouraged to join diabetic association where you can get adequate information and help. Deficiency in the production of insulin by the beta cells, delayed or insufficient release of insulin, excessive inactivation of insulin by chemical inhibitors or insensitivity of insulin secretory mechanism of the beta cells lead to a disproportion between blood glucose levels and insulin secretion.
The absence of insulin action leads to impairment in the ability to maintain normal fasting blood glucose bringing about accumulation of glucose in the blood since it cannot enter into muscles and fat cells. The accumulation of glucose raises the blood sugar level (hyperglycaemia). Excess sugar in the blood suppresses the renal tubular re-absorption mechanism for glucose; the level may rise above 180mg/100ml of blood. This gives way for some of it to be excreted in the urine (glucosuria).
The high molecular weight of glucose ensures that water is pulled along with it as it is excreted, leading to excessive output of urine (polyuria). Uncontrollable loss of excess quantity of water from the body results in excessive thirst and high water intake (polydipsia). Dehydration occurs if the quantity of water the patient takes is not commensurate with the quantity lost through the urine.
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