So it is with interest that a new market The Oxidized Cholesterol Strategy Review is being opened for another statin drug, Crestor. This market of 6.5 million in the USA do not have raised cholesterol or any sign of heart disease but satisfy three other criteria for "risk" of heart disease, including age.This new use has FDA approval. Yet the same FDA is cautioning about the side effect of muscle damage with use of simvastain and has previously issued warnings about use of doses greater than 20mg in certain patient groups. A new trial has suggested statin drugs could increase the risk of Type 2 Diabetes.
According to the American College of Cardiology, sudden cardiac death accounts for 400,000 mortalities a year in the United States. And pursuant to a recent study conducted by Yale University, angry outbursts may account for a fair proportion of that depressing figure. The researchers, led by cardiologist Rachel Lampert, invited 62 patients with heart disease to re-live an event from their lives which they had found infuriating. Each of the patients wore implanted cardioverter-defibrillators (ICDs), small devices which sense irregular heart rhythms and deliver tiny electrical charges to the heart muscle in order to re-establish a healthy heartbeat and protect against full cardiac arrest.
Ingeniously, as the patients recounted the event, the researchers asked them questions which had been carefully crafted to escalate their angry feelings. In the language of the scientists, the patients were taking part in a 'mental stress protocol'. The patients' physiological responses were monitored via an EKG while they described their infuriating experiences. The study found that, even without the annoying questions, the subjects displayed irregular heartbeats ("T-wave Alternans") simply by thinking about the event.
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