Fruits should be taken in moderation Phytage Labs Gluco Type 2 Review since they have high starch and sugar content.Diabetes mellitus is a common disorder characterized by an insufficient secretion of insulin or insulin-resistance by the major target tissues (skeletal muscle, liver, and adipocytes). A severe metabolic acidosis may develop in uncontrolled diabetes mellitus.
Acidosis occurs because insulin deficiency leads to decreased glucose utilization, a diversion of metabolism toward the utilization of fatty acids, and an overproduction of ketone body acids (acetoacetic acid and _-hydroxybutyric acids). Ketone body acids are fairly strong acids (pKa 4 to 5); they are neutralized in the body by HCO3_ and other buffers. Increased production of these acids leads to a fall n plasma [HCO3 _], an increase in plasma anion gap, and a fall in blood pH (acidemia).
Severe acidemia, whatever its cause, has many adverse effects on the body. It impairs myocardial contractility, resulting in a decrease in cardiac output. It causes arteriolar dilation, which leads to a fall in arterial blood pressure. Hepatic and renal blood flows are decreased. Reentrant arrhythmias and a decreased threshold for ventricular fibrillation can occur.
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