Product Name: Indapamide
CAS: 26807-65-8
Standard: Corporate Standard
Natural/Synthetic: Synthetic
Source of extraction: for export only
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 25 / cardboard drum can be split
Field: Diuretic antihypertensive drugs
Deferred Products: Indapamide Tablets, Indapamide Capsules, Indapamide Sustained Release Tablets
Use: For the treatment of mild to moderate essential hypertension
Dosage: Adults: conventional oral dose 1. Hypertension: 2.5mg each time, once daily. It can be increased to 5 mg once daily after 4 weeks. The maintenance dose is 2.5mg each time, every other day. 2. Water and sodium retention: Each 2.5mg, once daily. It can be increased to 5 mg once daily after 1 week. Elderly dose: dosage.
High Quality Indapamide 99% CAS: 26807-65-8
Brief Introduction of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
2. White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.
3. Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Medical Application of Active Pharmaceutical Ingredients Indapamide:
1. This medication is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.
2. Indapamide is a "water pill" (diuretic) that increases the amount of urine you make. Getting rid of extra water and salt may help to relax the blood vessels so that bloodcan flow more easily. These effects help to lower blood pressure and decrease the amount of work the heart must do to pump blood.
Function of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
2. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function.